The embrace of the people to their expression in life and art.

Confinement and social isolation during the COVID-19 pandemic limited close physical contact, especially close ones, of which hugs stand out. The social impact of emptiness and affective isolation still endures. The hug is an innate affective response of the human being that is expressed in different circumstances. It originates from different brain regions, ranging from limbic to cortical, in which a complex interaction between afferents, signaling systems, and neurotransmitters is intertwined, conditioning a neurohormonal response with multisystem impact. The hug goes beyond this complex substrate, it represents the sublimation of the merely anatomical and physiological, to the affective manifestation of the human spirit. The objective of this brief essay is to put to your consideration the neuroscientific bases of the hug and its expression in the complexity of life and art. (English) [ FROM AUTHOR] El confinamiento y aislamiento social durante la pandemia por COVID-19 limitaron el contacto físico estrecho, en especial los de cercanía, del que destacan los abrazos. El impacto social del vacío y aislamiento afectivo aún perdura. El abrazo es una respuesta innata afectiva del ser humano que se expresa en diferentes circunstancias. Tiene su origen en diferentes regiones cerebrales, que van de las límbicas a las corticales, en las que se entrelaza una compleja interacción entre aferencias, sistemas de señalización y neurotransmisores que condicionan una respuesta neurohormonal con impacto multisistémico. El abrazo va más allá de este complejo sustrato, representa la sublimación de lo meramente anatómico y fisiológico, a la manifestación afectiva del espíritu humano. El objetivo de este breve ensayo es poner a su consideración las bases neurocientíficas del abrazo y su expresión en la complejidad de la vida y el arte. (Spanish) [ FROM AUTHOR] Copyright of Revista Mexicana de Anestesiologia is the property of Colegio Mexicano de Anestesiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Vaccine hesitancy and the willingness to recommend the COVID-19 vaccine to children in a rural country on the United States-Mexico border.

Introduction: As of October 26, 2022, only 9% of children in the United States aged 6 months to 4 years have received at least one dose of COVID-19 vaccine despite FDA approval since June 17, 2022. Rates are better yet still low for children aged 5 to 11 years as nearly 30% were fully vaccinated as of August 23, 2022. Vaccine hesitancy among adults is one of the major factors affecting low vaccine uptake rates in children against COVID-19, yet most studies examining vaccine hesitancy have targeted school-age and adolescent children. Methods: With the aim of assessing the willingness to recommend the COVID-19 vaccination to children under 5 years compared to children 5 to 12 years of age, a county-wide survey was conducted between January 11 and March 7, 2022, among adults on the United States-Mexico border. Results: Among the 765 responses, 72.5% were female and 42.3% were Latinx. The most significant factor associated with likelihood to recommend the COVID-19 vaccine to children less than 5 years and 5-12 years of age was adult vaccination status. Ordinal logistic regression also indicated that ethnicity, primary language, being a parent, previous COVID-19 infection, and concern about getting COVID-19 in the future were significantly associated with likelihood of COVID-19 vaccine recommendation to children < 5 years and 5-12 years old. Discussion: This study found high consistency among respondents in their willingness to vaccinate children aged < 5 years compared with children aged 5-12 years. Our findings support public health strategies that target adult vaccinations as an avenue to improve childhood vaccinations for young children.

The Arizona Prevention Research Center partnerships in Arizona to promote COVID-19 vaccine health equity.

Background: Vaccine hesitancy in the face of the COVID-19 pandemic is a complex issue that undermines our national ability to reduce the burden of the disease and control the pandemic. The COVID-19 pandemic revealed widening health disparities and disproportionate adverse health outcomes in terms of transmission, hospitalizations, morbidity and mortality among Arizona's Latinx rural, underserved, farmworker, disabled and elderly populations. In March 2021, ~8.1% of those vaccinated were Latinx, though Latinxs make up 32% of Arizona's population. The Arizona Vaccine Confidence Network (AzVCN) proposed to leverage the expertise of the Arizona Prevention Research Center (AzPRC) and the resources of the Mel and Enid Zuckerman College of Public Health (MEZCOPH) Mobile Health Unit (MHU) to identify, implement and evaluate a MHU intervention to increase uptake of COVID-19 vaccines. Methods: The AzVCN focused efforts on Latinx, rural, un/underinsured and farmworker communities in the four Arizona border counties that are at greater risk of COVID-19 morbidity and mortality and may have limited access to vaccination and other essential health services. The AzVCN used listening sessions to create a feedback loop with key stakeholders and critical health care workers to validate barriers/enablers and identify solutions to increase vaccination uptake emerging from the network. The AzVCN also implemented a community-based intervention using community health workers (CHWs) based in a MHU to increase knowledge of the COVID-19 vaccines, reduce vaccination hesitancy and increase vaccination uptake among Latinx rural, un/underinsured and farmworker populations in Southern Arizona. Results: AzVCN outcomes include: identification of enablers and barriers of COVID-19 vaccination in the priority populations; identification of strategies and solutions to address vaccine hesitancy and increase vaccine uptake among priority population; and evidence that the proposed solutions being tested through the AzVCN contribute to increased vaccine uptake among the priority populations. Conclusion: Through these efforts the AzPRC contributed to the CDC's Vaccinate with Confidence Strategy by collaborating with CHWs and other key stakeholders to engage directly with communities in identifying and addressing structural and misinformation barriers to vaccine uptake.

Consecuencias de la covid-19 en la economía y las finanzas públicas en México: más allá de la pandemia *

La crisis sanitaria generada por la acelerada propagación en el planeta del virus sarsCoV2 -fuente de la enfermedad covid-19- ha tenido un impacto negativo inevitable en los sistemas de salud y, simultáneamente, en la dinámica de las economías global, regional y nacional. Los problemas estructurales de la economía mexicana y la estrechez del espacio fiscal no surgieron con la pandemia, se fueron configurando durante las últimas tres décadas mediante la implementación del modelo económico que privilegió las políticas orientadas al mercado y el retiro de la intervención del Estado en la economía, en busca de una supuesta eficiencia en la asignación de los recursos y los factores productivos. En este artículo se analiza el impacto de la covid-19 en la economía y la hacienda pública de México, desde una perspectiva que plantea la existencia previa de las debilidades estructurales de la economía, a fin de buscar mayor dinamismo de la producción, el ingreso, la inversión productiva, la generación de empleo y la productividad laboral. También se plantea que las crisis de salud y económica representan una oportunidad para impulsar un nuevo modelo económico que trascienda las políticas económicas de raíz neoliberal, mediante el diseño y la instrumentación de una política para la transformación y la diversificación productivas, el desarrollo industrial, la innovación, la ciencia y la tecnología. Se busca un nuevo modelo económico que vaya más allá de la pandemia para el desarrollo de capacidades productivas y tecnológicas en el que la política económica no sea un fin para la estabilidad macroeconómica, sino un medio para alcanzar el objetivo central de bienestar social de la población.Alternate :The health crisis generated by the accelerated spread on the planet of the sars-CoV2 virus - the source of the covid-19 disease-has had an inevitable negative impact on health systems and simultaneously on the dynamics of the global, regional, and national economies. The structural problems of the Mexican economy and the narrowness of the fiscal space did not arise with the pandemic, they were configured during the last three decades with the implementation of the economic model that privileged market-oriented policies and the withdrawal of state intervention in the economy., in search of a supposed efficiency in the allocation of resources and productive factors. This article analyzes the impact of the covid-19 disease on the economy and public finances of Mexico, within a perspective that raises the previous existence of structural weaknesses in the economy to generate greater dynamism in production, income, productive investment, job creation, and labor productivity. The health and economic crises represent an opportunity to promote a new economic model that transcends the policies of neoliberal roots, through the design and implementation of an economic policy for the transformation and diversification of production, industrial development, innovation, science, and technology. A new economic model that goes beyond the pandemic, for the development of productive and technological capacities in which economic policy is not an end for macroeconomic stability, but a means to achieve the central objective of social welfare of the population.

Consequences of covid-19 on the economy and public finance in Mexico: Beyond the pandemic.

The health crisis generated by the accelerated spread on the planet of the sars-CoV2 virus—the source of the covid-19 disease—has had an inevitable negative impact on health systems and simultaneously on the dynamics of the global, regional, and national economies. The structural problems of the Mexican economy and the narrowness of the fiscal space did not arise with the pandemic, they were configured during the last three decades with the implementation of the economic model that privileged market-oriented policies and the withdrawal of state intervention in the economy., in search of a supposed efficiency in the allocation of resources and productive factors. This article analyzes the impact of the covid-19 disease on the economy and public finances of Mexico, within a perspective that raises the previous existence of structural weaknesses in the economy to generate greater dynamism in production, income, productive investment, job creation, and labor productivity. The health and economic crises represent an opportunity to promote a new economic model that transcends the policies of neoliberal roots, through the design and implementation of an economic policy for the transformation and diversification of production, industrial development, innovation, science, and technology. A new economic model that goes beyond the pandemic, for the development of productive and technological capacities in which economic policy is not an end for macroeconomic stability, but a means to achieve the central objective of social welfare of the population. (English) [ FROM AUTHOR] La crisis sanitaria generada por la acelerada propagación en el planeta del virus sars- CoV2 —fuente de la enfermedad covid-19— ha tenido un impacto negativo inevitable en los sistemas de salud y, simultáneamente, en la dinámica de las economías global, regional y nacional. Los problemas estructurales de la economía mexicana y la estrechez del espacio fiscal no surgieron con la pandemia, se fueron configurando durante las últimas tres décadas mediante la implementación del modelo económico que privilegió las políticas orientadas al mercado y el retiro de la intervención del Estado en la economía, en busca de una supuesta eficiencia en la asignación de los recursos y los factores productivos. En este artículo se analiza el impacto de la covid-19 en la economía y la hacienda pública de México, desde una perspectiva que plantea la existencia previa de las debilidades estructurales de la economía, a fin de buscar mayor dinamismo de la producción, el ingreso, la inversión productiva, la generación de empleo y la productividad laboral. También se plantea que las crisis de salud y económica representan una oportunidad para impulsar un nuevo modelo económico que trascienda las políticas económicas de raíz neoliberal, mediante el diseño y la instrumentación de una política para la transformación y la diversificación productivas, el desarrollo industrial, la innovación, la ciencia y la tecnología. Se busca un nuevo modelo económico que vaya más allá de la pandemia para el desarrollo de capacidades productivas y tecnológicas en el que la política económica no sea un fin para la estabilidad macroeconómica, sino un medio para alcanzar el objetivo central de bienestar social de la población. (Spanish) [ FROM AUTHOR] Copyright of Trimestre Económico is the property of Fondo de Cultura Economica / Mexico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro.

Quinacrine (Qx), a molecule used as an antimalarial, has shown anticancer, antiprion, and antiviral activity. The most relevant antiviral activities of Qx are related to its ability to raise pH in acidic organelles, diminishing viral enzymatic activity for viral cell entry, and its ability to bind to viral DNA and RNA. Moreover, Qx has been used as an immunomodulator in cutaneous lupus erythematosus and various rheumatological diseases, by inhibiting phospholipase A2 modulating the Th1/Th2 response. The aim of this study was to evaluate the potential antiviral effect of Qx against denominated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Vero E6 cells. The cytotoxicity of Qx in Vero E6 cells was determined by the MTT assay. Afterwards, Vero E6 cells were infected with SARS-CoV-2 at different multiplicities of infections (MOIs) of 0.1 and 0.01 in the presence of Qx (0-30 µM) to determinate the half maximal effective concentration (EC50). After 48 h, the effect of Qx against SARS-CoV-2 was assessed by viral cytotoxicity and viral copy numbers, the last were determined by digital real-time RT-PCR (ddRT-PCR). Additionally, electron and confocal microscopy of Vero E6 cells infected and treated with Qx was studied. Our data show that Qx reduces SARS-CoV-2 virus replication and virus cytotoxicity, apparently by inhibition of viral ensemble, as observed by ultrastructural images, suggesting that Qx could be a potential drug for further clinical studies against coronavirus disease 2019 (COVID-19) infection.